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Martin Brecher Selected Research

Quetiapine Fumarate (Seroquel)

5/2010Long-term symptomatic remission of schizophrenia with once-daily extended release quetiapine fumarate: post-hoc analysis of data from a randomized withdrawal, placebo-controlled study.
3/2010Safety and tolerability of once-daily extended release quetiapine fumarate in acute schizophrenia: pooled data from randomised, double-blind, placebo-controlled studies.
2/2010A double-blind, placebo-controlled study of quetiapine and paroxetine as monotherapy in adults with bipolar depression (EMBOLDEN II).
2/2010A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I).
1/2010A failed 6-week,randomized, double-blind, placebo-controlled study of once-daily extended release quetiapine fumarate in patients with acute schizophrenia: lessons learned.
4/2009Extended-release quetiapine as adjunct to an antidepressant in patients with major depressive disorder: results of a randomized, placebo-controlled, double-blind study.
4/2009A 24-week, multicenter, open-label, randomized study to compare changes in glucose metabolism in patients with schizophrenia receiving treatment with olanzapine, quetiapine, or risperidone.
4/2009Maintenance treatment for patients with bipolar I disorder: results from a north american study of quetiapine in combination with lithium or divalproex (trial 127).
4/2009Extended release quetiapine fumarate monotherapy in major depressive disorder: a placebo- and duloxetine-controlled study.
3/2009Pharmacokinetic profiles of extended release quetiapine fumarate compared with quetiapine immediate release.
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Martin Brecher Research Topics

Disease

14Schizophrenia (Dementia Praecox)
05/2010 - 07/2003
9Sleepiness
02/2010 - 01/2005
8Mania (Manias)
02/2010 - 01/2005
7Bipolar Disorder (Manic Depressive Psychosis)
02/2010 - 01/2005
6Dizziness (Lightheadedness)
02/2010 - 06/2005
4Weight Gain
04/2007 - 01/2005
3Nausea
02/2010 - 04/2009
3Headache (Headaches)
02/2010 - 08/2008
3Psychotic Disorders (Schizoaffective Disorder)
03/2009 - 07/2003
3Psychomotor Agitation (Akathisia)
01/2007 - 10/2005
2Sleep Initiation and Maintenance Disorders (Insomnia)
02/2010 - 01/2005
2Major Depressive Disorder (Major Depressive Disorders)
04/2009 - 04/2009
2Neuroblastoma
09/2007 - 04/2005
2Neoplasms (Cancer)
09/2007 - 04/2005
2Tremor (Tremors)
10/2006 - 01/2005
1Insulin Resistance
04/2009
1Hypothyroidism
04/2009
1Nasopharyngitis
08/2008
1Neuroectodermal Tumors (Neuroectodermal Tumor)
09/2007
1Orthostatic Hypotension (Postural Hypotension)
01/2007
1Asthenia
01/2007
1Pharyngitis (Sore Throat)
01/2007
1Melanoma (Melanoma, Malignant)
04/2005

Drug/Important Bio-Agent (IBA)

26Quetiapine Fumarate (Seroquel)FDA Link
05/2010 - 07/2003
6LithiumIBA
02/2010 - 01/2005
3Antipsychotic Agents (Antipsychotics)IBA
05/2010 - 07/2003
3Valproic Acid (Depakote)FDA LinkGeneric
08/2008 - 01/2007
3Haloperidol (Haldol)FDA LinkGeneric
10/2006 - 07/2003
2Risperidone (Risperdal Consta)FDA LinkGeneric
04/2009 - 11/2006
2VaccinesIBA
09/2007 - 04/2005
2GD2 gangliosideIBA
09/2007 - 04/2005
1Paroxetine (Paxil)FDA LinkGeneric
02/2010
1Antidepressive Agents (Antidepressants)IBA
04/2009
1Insulin (Novolin)FDA Link
04/2009
1LipidsIBA
04/2009
1Duloxetine Hydrochloride (Cymbalta)FDA Link
04/2009
1Olanzapine (Zyprexa)FDA Link
04/2009
1Glucose (Dextrose)FDA LinkGeneric
04/2009
1interleukin-21 (interleukin 21)IBA
09/2007
1Immunoglobulin M (IgM)IBA
09/2007
1CarbohydratesIBA
09/2007
1AntigensIBA
09/2007
1CytokinesIBA
09/2007
1Interleukin-15 (Interleukin 15)IBA
09/2007
1Cholinergic Antagonists (Anticholinergics)IBA
10/2006
1Pharmaceutical PreparationsIBA
10/2006
1AntibodiesIBA
04/2005
1Peptides (Polypeptides)IBA
04/2005
1Complement System Proteins (Complement)IBA
04/2005
1Peptide LibraryIBA
04/2005
1Monoclonal AntibodiesIBA
04/2005
1Immunoglobulins (Immunoglobulin)IBA
04/2005

Therapy/Procedure

3Therapeutics
01/2007 - 09/2004
1Secondary Prevention
05/2010
1Immunotherapy
09/2007